HPLC profile of radioactivity elution for bile duct-cannulated dog urine samples from the day 1 collection period
| Dog | Gender | Sample Radioactivity | |
|---|---|---|---|
| Acyl glucuronides | Zopolrestat | ||
| % of total | |||
| 35014 | M | 57 | 43 |
| 35016 | M | 73 | 27 |
| 04710 | F | <203-a | >803-a |
| 05020 | F | 61 | 39 |
| Mean ± SD | 64 ± 7 | 36 ± 7 | |
↵3-a Only drug was detected by the β-RAM. The presence of glucuronide was confirmed by MS data. This data point was not included in the mean/SD calculations.