Metabolite No. | HPLC Retention Time | Molecular Ion | Elimination Routea | Description of Metabolite Structure | ||
---|---|---|---|---|---|---|
Plasma | Bile | Urine | ||||
min | m/z | |||||
5 | 17.5 | 539 | Y | Y | Benzothiazole cysteine conjugate | |
11 | 26 | 612 | Y | Phthalazinone oxidation product and glucuronic acid conjugate | ||
15 | 25–33 | 436 | Y | Y | Y | Single oxidation of phthalazinone moiety product |
16 | 25–33 | 436 | Y | Y | Y | Single oxidation of phthalazinone moiety product |
17 | 25–33 | 436 | Y | Y | Y | Single oxidation of phthalazinone moiety product |
18 | 23–28 | 596 | Y | Y | Y | Acyl glucuronide conjugate |
Y, presence of metabolite in the matrix noted.