Mean parameters of fluoxetine and norfluoxetine obtained after sc infusion of fluoxetine (12.5 μg/hr) in transgenic and control mice
| Parameter | Fluoxetine | Norfluoxetine | ||
|---|---|---|---|---|
| Transgenic | Control | Transgenic | Control | |
| C ss, serum (ng/ml) | 354.5 ± 61.7 | 278.9 ± 26.7 | 681.7 ± 58.73-a | 466.8 ± 22.3 |
| C ss, brain (ng/g) | 3406.0 ± 348.83-a | 6302.1 ± 365.2 | 6983.6 ± 601.33-a | 8914.5 ± 809.6 |
| Brain-to-serum ratio | 11.4 ± 1.43-a | 26.5 ± 3.4 | 12.3 ± 1.83-a | 20.6 ± 1.2 |
| Cl s(ml/min/kg) | 33.3 ± 4.2 | 42.1 ± 2.3 | ||
↵3-a Significantly different from control values (p < 0.05).