Table 1

Percentages of administered dose excreted in urine and feces from male and female dogs after a single oral dose of ¹⁴C-RWJ-26240 (6 mg/kg)

Time (hr)	Males (% Dose)		Females (% Dose)		Mean	SD
Time (hr)	1	2	3	4	Mean	SD	5	6
A. Total Urinary Recovery
0–24	2.33	2.29	1.25	2.17	2.15	1.87	2.01	0.41
24–48	0.54	0.41	0.42	0.39	0.67	0.19	0.44	0.16
48–72	0.19	0.17	0.19	0.14	0.28	0.11	0.18	0.06
72–96	0.11	0.13	0.11	0.10	0.14	0.07	0.11	0.02
96–168	0.06	0.06	0.08	0.10	0.09	0.06	0.08	0.02
Total (0–168)	3.23	3.06	2.05	2.90	3.33	2.30	2.81	0.52
B. Total Fecal Recovery
0–24	82.0	46.6	58.1	72.0	67.7	92.7	69.9	16.5
24–48	8.3	27.0	20.9	15.2	29.6	4.7	17.6	10.0
48–72	2.2	3.1	5.9	2.7	8.6	1.6	4.0	2.7
72–96	1.2	3.4	4.1	1.5	2.0	1.2	2.2	1.2
96–168	4.0	4.6	3.4	2.6	2.3	1.7	3.1	1.1
Total (0–168)	97.7	84.7	92.4	94.0	110.2	101.9	96.8	8.7