Per cent of total 14C and per cent of dose represented by RWJ-26240 and its metabolites in each sample
| Pooled Sample | Plasma (4-hr) | Urine (0–24 hr) | Fecal Extract (0–48 hr) | ||
|---|---|---|---|---|---|
| Sample Content | NA | 2% Dose | 73% Dose | ||
| Sample | Dose | Sample | Dose | ||
| I: RWJ-26240 | 36 | + | 26 | 19 | |
| M-1(RWJ-36359) | 16 | + | + | ||
| M-2(RWJ-37086) | 20 | 30 | 0.6 | 14 | 10 |
| M-3 | − | − | + | ||
| M-4(RWJ-36552) | + | + | 8 | 6 | |
| M-5 | − | − | + | ||
| M-6 | − | − | + | ||
| M-7 | − | − | 6 | 4 | |
| M-8(RWJ-37087) | + | + | + | ||
| M-9 | − | − | + | ||
| M-10 | − | − | + | ||
| M-11 | − | + | + | ||
| M-12(homoveratric acid) | + | + | + | ||
+ presents at <5% of total 14C in sample.
− none detected.