Pharmacokinetic parameters calculated from plasma concentrations of TCA-precipitable radioactivity in W/Wv and +/+ mice after intravenous administration of 125I-rh-EPO at the dose of 0.48 μg/kg
| Vc (ml/kg) | Vss (ml/kg) | AUC (ng hr/ml) | MRT (hr) | CLtotal (ml/kg/hr) | |
|---|---|---|---|---|---|
| W/Wv | 67.5 (7.7) | 119 (14) | 19.4 (1.3) | 4.83 (0.66) | 24.7 (1.6) |
| +/+ | 52.3 (3.3) | 99.1 (8.5) | 20.8 (1.8) | 4.30 (0.40) | 23.0 (0.9) |
Values in parenthesis represent computer calculated SD.