Kinetic parameters for tissue uptake clearance in +/+ and W/Wvmice2-a
| Km,app | Vmax | CLns | ||
|---|---|---|---|---|
| W/Wvmice | femur | 10.0 (544 pM) ± 4.1 mg/ml | 3.35 ± 1.17 ng/g tissue/hr | 0.105 ± 0.019 ml/g tissue/hr |
| spleen | 7.93 (431 pM) ± 8.14 ng/ml | 2.01 ± 1.70 ng/g tissue/hr | 0.182 ± 0.034 ml/g tissue/hr | |
| +/+ mice | femur | 11.4 (619 pM) ± 4.2 ng/ml | 7.80 ± 2.36 ng/g tissue/hr | 0.069 ± 0.033 ml/g tissue/hr |
| spleen | 7.15 (389 pM) ± 2.97 ng/ml | 5.94 ± 1.88 ng/g tissue/hr | 0.132 ± 0.039 ml/g tissue/hr |
↵2-a mean ± calculated SD.