Sex | Absorption Rate (mg/cm2/hr) | Permeability Constant4-aKp (cm/hr) |
---|---|---|
Calculation based on CO2recovery4-b | ||
Male | 0.78 ± 0.03 | 1.37 × 10−3 |
Female | 0.77 ± 0.13 | 1.35 × 10−3 |
Calculation based on total recovery of radioactivity4-c | ||
Male | 0.85 ± 0.04 | 1.50 × 10−3 |
Female | 0.78 ± 0.16 | 1.37 × 10−3 |
↵4-a Calculations are based on a density of 0.814 g/ml for 70% IPA or a concentration of 568.5 mg/ml IPA.
↵4-b The fraction (percentage) of an administered iv dose converted to CO2 was used as a correction factor to calculate the fraction of dermally absorbed dose.
↵4-c The total recovered radioactivity (percentage) from an iv dose was used as a correction factor to calculate the fraction of dose absorbed dermally based on total recovery of radioactivity from urine, cage wash, feces, and expired CO2 and volatiles.