Pharmacokinetic parameters for renal tubular transport of MBCA enantiomers based on the two-compartment, well-stirred model
| Perfused Chemicals | k1 | k1/fp | k2 | Vd,cell |
|---|---|---|---|---|
| sec−1 | sec−1 | sec−1 | ml | |
| (R)-(+)-MBCA | 0.76 ± 0.09 | 3.60 ± 0.42 | 0.0073 ± 0.0020 | 64.2 ± 17.5 |
| (S)-(−)-MBCA | 0.22 ± 0.09 | 2.23 ± 0.95 | 0.0070 ± 0.0020 | 28.5 ± 3.6 |
| p 5-a | <0.0005 | <0.05 | NS | <0.005 |
Results are expressed as the mean ± SD of at least four experiments.
↵5-a Probability level for comparison between enantiomers. NS, not significant.