Table 1

In vivo disposition parameters for ethoxycoumarin

Based on Total Drug Concentration1-aBased on Unbound Drug Concentration1-b
V max(nmol/min/SRW)495  ± 15495
K M (μM)16.5  ± 1.13.6
CL int(ml/min/SRW)30137
CL H(ml/min/SRW)12
  • 1-a Steady-state blood concentration data from 30 rats (blood/plasma concentration, 0.98); parameter values (mean ± SE) from nonlinear regression analysis are shown.

  • 1-b Steady-state concentration data divided by the plasma unbound fraction of 0.22.