Table 4

Kinetics of ethoxycoumarin depletion in microsomes and hepatocytes

	Initial EC Concentration	Half-life	AUC	CL_int
	μM	min	nmol/ml/min	μl/min
Microsomes^4-a	1.54 ± 0.23	19 ± 8	42 ± 12	81 ± 30
Hepatocytes^4-b	1.04 ± 0.17	88 ± 31	135 ± 31	98 ± 28

Data are presented as mean ± SD (N = 6).
↵4-a AUC and CL_int are expressed per milligram of microsomal protein (incubation concentration used, 0.5 mg protein/ml).
↵4-b AUC and CL_int are expressed per 10⁶ cells (incubation concentration used, 0.25 × 10⁶/ml.).