Pharmacokinetic parameters for blood and tissues after ip administration of tBCEU labeled in the urea function (label 1) or chloroethyl function (label 3)
| Tissue | Label 1 | Label 3 | ||
|---|---|---|---|---|
| t1/2(Elimination) | AUC0→∞ | t1/2(Elimination) | AUC0→∞ | |
| hr | hr · nmol/g | hr | hr · nmol/g | |
| Blood | 4.71 ± 0.27 | 352.05 ± 37.42 | 7.02 ± 0.35 | 339.02 ± 40.27 |
| Liver | 6.23 ± 0.45 | 535.52 ± 57.55 | 9.34 ± 0.81 | 528.25 ± 48.52 |
| Kidney | 7.47 ± 0.54 | 391.18 ± 32.27 | 10.54 ± 0.78 | 412.16 ± 25.59 |
| Spleen | 6.56 ± 0.32 | 145.28 ± 12.59 | 9.21 ± 0.55 | 124.42 ± 10.23 |
| Heart | 8.38 ± 0.86 | 109.42 ± 10.24 | 11.45 ± 0.98 | 120.55 ± 14.65 |
| Stomach | 6.35 ± 0.41 | 570.58 ± 85.62 | 9.52 ± 0.51 | 489.78 ± 55.52 |
| Colon | 7.28 ± 0.65 | 421.32 ± 27.85 | 11.12 ± 1.01 | 378.56 ± 15.44 |
| Muscle | 7.40 ± 0.42 | 62.81 ± 5.74 | 10.28 ± 0.66 | 55.24 ± 6.51 |
| Brain | 8.87 ± 0.61 | 68.61 ± 8.42 | 12.44 ± 0.88 | 72.41 ± 4.52 |
Values are from three animals (five slices/animal) (mean ± SD).