50 mg/kg (N = 4) | 100 mg/kg (N = 8) | 300 mg/kg (N = 12) | 500 mg/kg (N = 10) | |
---|---|---|---|---|
YH439 | ||||
AUC0→ t (μg min/ml) | 31.8 ± 3.73 | 34.6 ± 12.1 | 37.2 ± 14.2 | |
Ae(∞) (μg) | 2.86 ± 1.15 | 2.67 ± 3.15 | 0.884 ± 0.890 | 2.90 ± 3.87 |
M4 | ||||
AUC0–12 hr (μg min/ml) | 63.0 ± 22.2 | 86.7 ± 8.25 | 132 ± 44.2 | |
Ae(∞)(μg) | 5.23 ± 1.76 | 8.05 ± 3.48 | 10.5 ± 3.79 | |
M5 | ||||
AUC0–12 hr (μg min/ml) | 214 ± 76.4 | 266 ± 77.3 | 296 ± 71.9 | 304 ± 97.7 |
Ae(∞) (μg) | 9.27 ± 3.48 | 49.3 ± 25.4 | 42.3 ± 26.7 | 59.7 ± 32.6 |