Table 7

Mean (±SD) pharmacokinetic parameters of M4 and M7 after oral administration of YH439 (0.5, 1, and 2 g per whole body weight) to dogs (N = 5 by crossover design)

0.5 g1 g2 g
M4
 AUC0→ t(μg·min/ml)133  ± 37.9162  ± 94.0242  ± 120
 CLR(ml/min/kg)7-a 0.00457  ± 0.001120.00831  ± 0.004170.00929  ± 0.00270
 Ae(∞)(μg)7-b 5.88  ± 1.9413.6  ± 8.4320.3  ± 6.56
M7
 AUC0→ t(μg·min/ml)7-b 47.9  ± 72.073.5  ± 57.7
 CLR (ml/min/kg)0.777  ± 0.5140.362  ± 0.340
 Ae(∞) (μg)286  ± 411260  ± 116

  • ↵7-a 0.5 g was significantly different (* p < 0.05) from 1 and 2 g.

  • ↵7-b 0.5 g was significantly different (* p < 0.05) from 2 g.