Pharmacokinetic parameters of tamsulosin after oral administration to dogs
| Parameter | Dose (mg/kg) | ||
|---|---|---|---|
| 0.3 | 1 | 3 | |
| Cmax (ng/ml) | 37 ± 3 | 146 ± 36 | 433 ± 50 |
| Tmax (h) | 0.13 ± 0.00 | 0.34 ± 0.10 | 0.50 ± 0.10 |
| AUC0–∞(ng·hr/ml) | 78 ± 9 | 259 ± 22 | 1100 ± 171 |
| t 1/2 (h) | 1.44 ± 0.11 | 1.68 ± 0.10 | 1.27 ± 0.05 |
| CLoral (l/hr/kg) | 3.99 ± 0.44 | 3.94 ± 0.32 | 3.01 ± 0.48 |
| F (%) | 29.8 ± 3.3 | 29.7 ± 2.5 | 42.0 ± 6.5 |
Values represent the mean ± SEM of four (0.3 and 1 mg/kg) or five (3 mg/kg) dogs.