Estimated parameter | Rats | Dogs | Humans |
---|---|---|---|
CLoral/fu (l/hr/kg) | 164–586 | 31–41 | 2.8–4.6 |
Vdss/fu (l/kg) | 13.6–14.7 | 17.6–17.9 | 18.6–22.86-a |
CLoral/fu: unbound oral clearance; Vdss/fu, distribution volume based on unbound tamsulosin.
Estimations use fu values determined using 14C-tamsulosin at the plasma concentration of 200 and 600 ng/ml.
↵6-a Mean value for Vdss in humans is 0.205 l/kg (Hoogdalem et al., 1997).