Effects of 1,7-phenanthroline, 2,2′-dipyridyl, and oltipraz on hepatic microsomal UGT activities
| UGT Aglycone | UGT Activities | |||
|---|---|---|---|---|
| Control | 1,7-Phenanthroline | 2,2′-Dipyridyl | Oltipraz | |
| nmol/mg/min | ||||
| 4-Nitrophenol | 4.48 ± 0.31 (10) | 11.39 ± 1.47 (5)2-a | 7.78 ± 0.80 (5)2-a | 7.91 ± 0.48 (5)2-a |
| 1-Naphthol | 40.4 ± 2.7 (8) | 73.2 ± 6.9 (5)2-a | 56.6 ± 3.5 (5)2-a | 62.9 ± 2.8 (3)2-a |
| 2-Hydroxybiphenyl | 1.27 ± 0.22 (5) | 3.40 ± 0.70 (4)2-a | 2.64 ± 0.29 (3)2-a | 1.81 ± 0.31 (2) |
| 4-Hydroxybiphenyl | 3.81 ± 1.25 (5) | 10.67 ± 2.00 (3)2-a | 5.16 ± 0.65 (3) | 2.89 ± 0.67 (2) |
| 2-Naphthol | 20.8 ± 3.3 (5) | 69.2 ± 12.4 (3)2-a | 31.1 ± 3.6 (3) | 55.0 (1)2-a |
| 4-Methylumbelliferone | 21.6 ± 5.4 (5) | 74.0 ± 14.5 (3)2-a | 56.9 ± 12.7 (4) | 74.2 ± 34.2 (2)2-a |
| Phenolphthalein | 1.49 ± 0.31 (5) | 1.51 ± 0.16 (4) | 1.47 ± 0.18 (4) | 1.00 (1) |
| Morphine | 6.43 ± 0.92 (8) | 18.40 ± 1.89 (5)2-a | 13.29 ± 0.99 (5)2-a | 10.55 ± 1.02 (3)2-a |
| Testosterone | 3.61 ± 0.18 (8) | 5.95 ± 0.23 (5)2-a | 4.35 ± 0.15 (5)2-a | 4.04 ± 0.27 (3) |
| Estrone | 0.063 ± 0.015 (8) | 0.085 ± 0.012 (5) | 0.096 ± 0.011 (5) | 0.013 ± 0.013 (3)2-a |
Animals were treated with the indicated agents at 75 mg/kg/day for 3 days, and microsomal fractions from the liver were prepared. Parameters determined are given as the mean ± SE. The numbers of samples examined are given in parentheses.
↵2-a Significant (p < 0.05) increases from values for untreated control animals.