Comparison of tissue concentrations of radioactivity in Sable Domestic male ferrets at 6, 16, and 30 min after oral administration of a single 10-mg/kg dose of 14C-labeled drug B4-a
| Tissue | 6 Min | 16 Min | 30 Min | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WBAL Mean ± SD | N | DLSA Mean ± SD | N | WBAL Mean ± SD | N | DLSA Mean ± SD | N | WBAL Mean ± SD | N | DLSA Mean ± SD | N | |
| Bile | <5.94-b | 3 ± 0.4 | 3 | 3673 ± 491 | 4 | 2534 | 1 | 1545 ± 281 | 4 | 1242 ± 169 | 3 | |
| Blood (vessel) | <5.94-b | 4 ± 1.3 | 3 | 30 ± 2 | 4 | 31 ± 2 | 3 | 16 ± 2 | 17 | 24 ± 6 | 3 | |
| Brain | <5.94-b | 1 ± 0.2 | 3 | 10 ± 1 | 4 | 10 ± 1 | 3 | 6 ± 1 | 4 | 6 ± 1 | 3 | |
| Esophageal contents | 2022 ± 502 | 18 | 2649 | 1 | 2460 ± 1258 | 8 | 3166 | 1 | 627 ± 50 | 3 | 680 | 1 |
| Kidney | 10 ± 0 | 9 | 9.8 ± 0.1 | 3 | 104 ± 6 | 30 | 119 ± 9 | 3 | 50 ± 11 | 27 | 107 ± 28 | 3 |
| Liver | 53 ± 4 | 21 | 51 ± 5 | 3 | 174 ± 29 | 28 | 168 ± 7 | 3 | 119 ± 10 | 25 | 110 ± 6 | 3 |
| Lung | 9 ± 1 | 29 | 9 ± 0.3 | 3 | 31 ± 3 | 18 | 40 ± 1 | 3 | 20 ± 2 | 27 | 23 ± 1 | 3 |
| Salivary gland | 7 ± 1 | 14 | 7 | 1 | 32 ± 2 | 8 | 38 | 1 | 18 ± 3 | 8 | 18 | 1 |
| Stomach contents | 2447 ± 195 | 28 | 2663 ± 251 | 3 | 1304 ± 318 | 14 | —4-c | 863 ± 118 | 31 | 871 | 1 | |
| Thymus | <5.94-b | 1 ± 0.1 | 3 | 14 ± 3 | 10 | 16 ± 1 | 3 | 12 ± 1 | 11 | 13 ± 1 | 3 | |