Enzyme kinetics for the formation of the 5-hydroxymethyl and N-dealkylated metabolites of tolterodine in pooled human liver microsomes
| Parameter | Metabolite | |
|---|---|---|
| 5-HM | N-Dealkylated Tolterodine | |
| V max (pmol/mg protein × min) | 317 | 687 |
| K m (μM) | 7 | 52 |
| CI i(μl/min × mg protein) | 47 | 13 |