Table 2

Correlation between the rate of formation of tolterodine metabolites and total P450 content and different P450 marker activities in human liver samples

MetabolismP450 IsoenzymeCorrelation (r2)
5-HMN-Dealkylated Tolterodine
Total P450 content—2-a 0.762-c
7-EthoxyresorufinO-dealkylation1A—2-a —2-a
Caffeine 3-demethylation1A2—2-a —2-a
Coumarin 7-hydroxylation2A6—2-a —2-a
Tolbutamide methyl-hydroxylation2C9—2-a 0.642-d
S-Mephenytoin 4-hydroxylation2C19—2-a —2-a
DextromethorphanO-demethylation2D60.872-b —2-a
Chlorzoxazone 6-hydroxylation2E1—2-a 0.22
Testosterone 6β-hydroxylation3A—2-a 0.972-b
Lauric acid 11-hydroxylation2E1—2-a 0.29
Lauric acid 12-hydroxylation4A—2-a 0.43
BenzphetamineN-demethylationUnknown—2-a 0.27

  • ↵2-a p > 0.2.

  • ↵2-b p < 0.0001.

  • ↵2-c p < 0.001.

  • ↵2-d p < 0.01.