Metabolism of tolterodine by microsomes from cells overexpressing P450 isoenzymes
| P450 Isoenzyme | Rate of Formation (pmol/pmol P450 × min) | |
|---|---|---|
| 5-HM | N-Dealkylated Tolterodine | |
| 1A1 | ND | ND |
| 1A2 | ND | ND |
| 2C8 | ND | ND |
| 2C9-Arg | ND | 0.25 ± 0.05 |
| 2C19 | ND | 1.51 ± 0.06 |
| 2D6 | 5.0 ± 0.35 | ND |
| 3A4 | ND | 0.23 ± 0.03 |
Data are mean ± SD of two experiments. ND, not detectable.