Michaelis-Menten kinetic parameters of arteether O-deethylation in human liver microsomes1-a
| Human Liver Donor | Km [AE] (μM) | Vmax (nmol DQHS/min/mg protein) | Clint (L/min) |
|---|---|---|---|
| 5 | 52.2 | 0.19 | 0.11 |
| 7 | 103.6 | 1.33 | 0.39 |
| 12 | 22.8 | 1.09 | 1.43 |
| 12A | 35.6 | 0.64 | 0.54 |
| 13 | 46.0 | 1.25 | 0.82 |
| 16 | 90.6 | 6.90 | 2.28 |
| 17 | 40.5 | 3.26 | 2.41 |
| 18 | 47.5 | 1.26 | 0.80 |
↵1-a Arteether at various concentrations was incubated with human liver microsomes. DQHS production was measured and the Michaelis-Menten parameters calculated as described in Materials and Methods. The mean of duplicate experiments for each human liver sample are shown.