Urinary and fecal excretion (0–72 hr) of radioactivity in Sprague-Dawley rats given single oral (6.25 mg/kg) or intravenous (0.5 mg/kg) doses of either [3H]MK-499 or [14C]MK-499
| Label | Radioactivity Excreted (% of Dose)1-a | |||
|---|---|---|---|---|
| PO | IV | |||
| Urine | Feces | Urine | Feces | |
| 3H | 10.5 ± 2.5 (N = 4) | 78.0 ± 7.4 (N = 4) | 21.2 ± 2.8 (N = 4) | 67.5 ± 6.0 (N = 4) |
| 14C | 9.1 ± 2.7 (N = 4) | 82.8 ± 9.0 (N = 4) | 23.3 ± 2.4 (N = 3) | 73.8 ± 4.3 (N = 3) |
↵1-a 3H values (mean ± SD) were from rats that weighed 265–315 g and received 1–2 μCi. 14C values (mean ± SD) were from rats that weighed 305–338 g and received 0.5–2 μCi.