C H,f/C p,f for CIM and NZD in rats
| Liver Concentration | Plasma Concentration | Kp,H | fH | fp | CH,f | Cp,f | CH,f/Cp,f | |
|---|---|---|---|---|---|---|---|---|
| CIM | 268.03 ± 90.46 μM | 72.53 ± 10.95 μM | 3.81 ± 0.66 | 0.42 ± 0.10 | 0.80 ± 0.10 | 112.57 ± 37.99 μM | 58.02 ± 8.76 μM | 1.94 |
| 67.64 ± 22.83 μg/g | 18.30 ± 2.76 μg/ml | 28.41 ± 8.74 μg/g | 14.64 ± 2.21 μg/ml | |||||
| NZD | 156.49 ± 8.81 μM | 50.59 ± 3.07 μM | 2.66 ± 0.80 | 0.74 ± 0.07 | 0.96 ± 0.08 | 115.80 ± 8.56 μM | 48.57 ± 2.94 μM | 2.38 |
| 51.85 ± 2.92 μg/g | 16.76 ± 1.02 μg/ml | 38.37 ± 2.84 μg/g | 16.09 ± 0.97 μg/ml |
Liver and plasma concentrations and Kp,H,fH, and fp values were determined in the experiments described in Materials and Methods.CH,f/Cp,f was calculated using those values.