Comparison of pharmacokinetic parameters of MK-499 in rats and dogs
| Rat | Dog | |||
|---|---|---|---|---|
| IV (0.5 mg/kg) | PO (6.25 mg/kg) | IV (2.5 mg/kg) | PO (3 mg/kg) | |
| t 1/2 (hr) | 4.6 | 7.1 | ||
| Cl (ml/min/kg) | 29 | 6.5 | ||
| C maxng/ml | 88 | 661 | ||
| [AUC]0–24(ng/hr/ml) | 283 | 622 | 5772 | 6882 |
| [AUC]0–∞(ng/hr/ml) | 289 | 6380 | ||
| Bioavail. (%) | 17 | 100 | ||
| V D (l/kg) | 11.5 | 4.3 | ||