Comparison between predicted and observed values for the increasing ratio of the plasma concentration of MDZ
| Ki | Rp | RH | AUC′/AUC | |
|---|---|---|---|---|
| μM | ||||
| CIM | 108 | 1.54 | 2.04 | 2.5 |
| NZD | 2562 | 1.02 | 1.05 | 1.0 |
The increasing ratios RH andRp were calculated from CH,fusing eq. 3 and from Cp,f using eq. 5, respectively. AUC′/AUC is the observed value calculated from the data in fig. 2.