Table 1

Induction of CYP1A1 activity by β-naphthoflavone in rat liver and subcompartments of rat lung

Compartment	CYP1A1		Fold Induction by β-Naphthoflavone^1-a
Compartment	Control	β-Naphthoflavone	Fold Induction by β-Naphthoflavone^1-a
	pmol/mg/min
Trachea	2.0 ± 0.6	4.9 ± 3.9^1-b	2.4
Airway	2.9 ± 0.8	81.3 ± 43.2^1-b	28.4
Lung parenchyma	6.0 ± 2.7	190 ± 91.8^1-b	31.5
Blood vessels	1.6 ± 0.6	26.3 ± 6.4^1-b	17
Liver	399 ± 128	3790 ± 2000^1-b	9.5

Values represent mean ± SD (N = 6 rats).
↵1-a Determined as the mean value of CYP1A1 activity for rats treated with β-naphthoflavone divided by the mean value of CYP1A1 activity for control animals.
↵1-b Significantly different, compared with CYP1A1 controls (p < 0.05).