Table 2

Influence of phenobarbital or acetone on P450 activities in rat liver and subcompartments of rat lung

CompartmentCYP2B1CYP2E1
ControlPhenobarbitalControlAcetone
pmol/mg/min pmol/mg/min
Trachea1.3  ± 0.32.9  ± 1.8ND2-a ND
Airway7.2  ± 3.85.5  ± 1.43.0  ± 2.01.4  ± 0.7
Lung parenchyma16.2  ± 7.425.6  ± 9.40.6  ± 0.21.0  ± 0.7
Liver43.8  ± 20.4564  ± 78.32-b 38.9  ± 3.4255  ± 14.42-b

  • Values represent mean ± SD (N = 4 rats).

  • ↵2-a ND, not detectable.

  • ↵2-b Significantly different, compared with respective controls (p < 0.05).