Group | Metabolite2-a | Excretion | ||||
---|---|---|---|---|---|---|
Until 4 hr | Until 8 hr | Until 24 hr | Until 48 hr | Until 72 hr | ||
% of dose | ||||||
A | TDA | 1.04 ± 1.22 | 4.47 ± 1.14 | 13.22 ± 3.18 | 13.62 ± 3.45 | 13.62 ± 3.45 |
TDA-SO | 0.67 ± 0.78 | 6.62 ± 4.77 | 23.70 ± 9.31 | 25.07 ± 8.84 | 25.18 ± 9.01 | |
2-HEMA | 0.79 ± 0.92 | 5.39 ± 2.68 | 24.17 ± 3.68 | 24.71 ± 3.31 | 24.71 ± 3.31 | |
M1 | 0.32 ± 0.38 | 2.09 ± 1.39 | 9.36 ± 7.01 | 9.70 ± 7.67 | 9.70 ± 7.67 | |
M2 | ND2-b | 0.10 ± 0.12 | 0.96 ± 0.80 | 1.24 ± 0.48 | 1.24 ± 0.48 | |
M3 | 0.16 ± 0.20 | 0.48 ± 0.22 | 1.17 ± 0.61 | 1.17 ± 0.61 | 1.17 ± 0.61 | |
M4 | ND | ND | ND | ND | ND | |
M5 | 0.13 ± 0.20 | 0.38 ± 0.25 | 0.84 ± 0.37 | 0.84 ± 0.37 | 0.84 ± 0.37 | |
M6 | ND | ND | ND | ND | ND | |
B | TDA | 0.80 ± 0.27 | 2.71 ± 0.91 | 7.64 ± 2.20 | 9.04 ± 2.91 | 9.16 ± 3.15 |
TDA-SO | 0.65 ± 0.23 | 2.17 ± 0.57 | 13.53 ± 4.58 | 18.71 ± 5.05 | 19.19 ± 5.15 | |
2-HEMA | 0.79 ± 0.25 | 3.44 ± 0.84 | 24.51 ± 2.34 | 33.41 ± 0.88 | 33.76 ± 0.74 | |
M1 | 0.20 ± 0.09 | 0.94 ± 0.10 | 6.35 ± 2.66 | 10.12 ± 2.59 | 10.15 ± 2.62 | |
M2 | 0.03 ± 0.05 | 0.16 ± 0.19 | 0.70 ± 0.67 | 1.66 ± 1.19 | 1.66 ± 1.19 | |
M3 | 0.19 ± 0.08 | 0.39 ± 0.16 | 0.92 ± 0.62 | 1.26 ± 0.74 | 1.26 ± 0.74 | |
M4 | ND | ND | ND | ND | ND | |
M5 | 0.20 ± 0.16 | 0.34 ± 0.20 | 0.88 ± 0.72 | 1.17 ± 0.92 | 1.20 ± 0.97 | |
M6 | ND | ND | ND | ND | ND | |
C | TDA | 4.81 ± 1.74 | 8.72 ± 1.84 | 11.76 ± 2.28 | 11.76 ± 2.28 | 11.76 ± 2.28 |
TDA-SO | 4.16 ± 1.64 | 11.68 ± 2.04 | 23.93 ± 2.84 | 25.50 ± 2.76 | 25.75 ± 2.77 | |
2-HEMA | 4.72 ± 1.51 | 12.11 ± 3.05 | 22.15 ± 1.44 | 22.15 ± 1.44 | 22.15 ± 1.44 | |
M1 | 2.04 ± 1.42 | 5.36 ± 3.14 | 7.31 ± 2.52 | 7.31 ± 2.52 | 7.31 ± 2.52 | |
M2 | 0.02 ± 0.05 | 1.12 ± 0.57 | 3.03 ± 1.24 | 3.03 ± 1.24 | 3.03 ± 1.24 | |
M3 | 1.24 ± 0.53 | 2.36 ± 0.48 | 3.39 ± 0.52 | 3.39 ± 0.52 | 3.39 ± 0.52 | |
M4 | ND | ND | ND | ND | ND | |
M5 | 1.11 ± 0.28 | 1.71 ± 0.28 | 2.19 ± 0.36 | 2.19 ± 0.36 | 2.19 ± 0.36 | |
M6 | ND | ND | ND | ND | ND | |
D | TDA | 1.44 ± 0.61 | 5.86 ± 1.31 | 10.60 ± 2.26 | 10.70 ± 2.39 | 10.70 ± 2.39 |
TDA-SO | 1.36 ± 0.54 | 5.12 ± 1.55 | 10.72 ± 3.36 | 11.88 ± 3.33 | 11.98 ± 3.45 | |
2-HEMA | 2.64 ± 0.74 | 10.79 ± 3.23 | 22.98 ± 1.69 | 23.80 ± 1.58 | 23.96 ± 1.43 | |
M1 | 0.58 ± 0.40 | 2.87 ± 1.77 | 7.42 ± 1.15 | 7.97 ± 0.98 | 7.97 ± 0.98 | |
M2 | 0.42 ± 0.35 | 1.45 ± 0.29 | 5.00 ± 1.14 | 5.46 ± 1.39 | 5.46 ± 1.39 | |
M3 | 0.95 ± 0.11 | 2.38 ± 0.38 | 3.65 ± 0.38 | 4.05 ± 0.31 | 4.10 ± 0.26 | |
M4 | ND | ND | 0.56 ± 0.39 | 0.56 ± 0.39 | 0.56 ± 0.39 | |
M5 | 1.59 ± 0.18 | 2.66 ± 0.15 | 3.64 ± 0.41 | 3.97 ± 0.33 | 4.02 ± 0.27 | |
M6 | ND | ND | 0.48 ± 0.40 | 0.48 ± 0.40 | 0.48 ± 0.40 |