Table 2

Pharmacokinetic parameters [mean and coefficient of variation (CV)] for total radioactivity after oral or iv administration of 1.0 mg/kg [¹⁴C]meloxicam to male and female albino rats (N = 5)

Parameter	Unit	Male		Female
Parameter	Unit	Mean	CV	Mean	CV
			%		%
Intravenous
AUC_0–∞	mg-eq·hr/liter	70.9	27.2	217	22.2
MRT_tot	hr	18.0	24.0	52.6	22.6
t _1/2	hr	13.4	21.5	36.8	22.2
V _z	liters/kg	0.277	9.13	0.247	8.03
V _ss	liters/kg	0.257	6.38	0.244	8.04
CL	liters/hr/kg	0.015	30.7	0.005	31.0
Oral
C _max	mg-eq/liter	2.35	33.0	3.23	37.1
t _max	hr	4.4	74.7	6.8	24.2
AUC_0–∞	mg-eq·hr/liter	83.3	57.1	201	47.7
MRT_tot	hr	31.8	25.4	53.4	20.5
t _1/2	hr	49.9	54.7	52.4	24.5
V _z/F	liters/kg	2.36	164	0.886	153
CL/F	liters/hr/kg	0.023	119	0.010	126