Parameter | Unit | Male | Female | ||
---|---|---|---|---|---|
Mean | CV | Mean | CV | ||
% | % | ||||
Intravenous | |||||
AUC0–∞ | mg-eq·hr/liter | 70.9 | 27.2 | 217 | 22.2 |
MRTtot | hr | 18.0 | 24.0 | 52.6 | 22.6 |
t 1/2 | hr | 13.4 | 21.5 | 36.8 | 22.2 |
V z | liters/kg | 0.277 | 9.13 | 0.247 | 8.03 |
V ss | liters/kg | 0.257 | 6.38 | 0.244 | 8.04 |
CL | liters/hr/kg | 0.015 | 30.7 | 0.005 | 31.0 |
Oral | |||||
C max | mg-eq/liter | 2.35 | 33.0 | 3.23 | 37.1 |
t max | hr | 4.4 | 74.7 | 6.8 | 24.2 |
AUC0–∞ | mg-eq·hr/liter | 83.3 | 57.1 | 201 | 47.7 |
MRTtot | hr | 31.8 | 25.4 | 53.4 | 20.5 |
t 1/2 | hr | 49.9 | 54.7 | 52.4 | 24.5 |
V z/F | liters/kg | 2.36 | 164 | 0.886 | 153 |
CL/F | liters/hr/kg | 0.023 | 119 | 0.010 | 126 |