Pharmacokinetic parameters [mean and coefficient of variation (CV)] for parent compound after iv, oral, or sc administration of 0.2 mg/kg meloxicam to male and female beagle dogs (N = 6)
| Parameter | Unit | Intravenous | |
|---|---|---|---|
| Mean | CV | ||
| % | |||
| AUC0–∞ | mg·hr/liter | 21.5 | 13.1 |
| AUCtf–∞ 4-a | % | 10.1 | 30.5 |
| MRTtot | hr | 34.8 | 23.6 |
| t 1/2 | hr | 24.0 | 26.2 |
| V z | liters/kg | 0.32 | 20.9 |
| CL | liters/hr/kg | 0.010 | 13.1 |
| Parameter | Unit | Oral | Subcutaneous | ||
|---|---|---|---|---|---|
| Mean | CV | Mean | CV | ||
| % | % | ||||
| C max | mg/liter | 0.464 | 12.7 | 0.734 | 15.9 |
| t max | hr | 7.5 | 110 | 2.5 | 74.8 |
| AUC0–∞ | mg·hr/liter | 22.9 | 16.0 | 24.1 | 16.3 |
| AUCtf–∞ | % | 10.7 | 36.4 | 10.1 | 29.3 |
| MRTtot | hr | 40.0 | 21.9 | 35.0 | 13.1 |
| t 1/2 | hr | 23.7 | 30.0 | 23.7 | 18.0 |
| V z/F | liters/kg | 0.30 | 18.3 | 0.28 | 10.0 |
| CL/F | liters/hr/kg | 0.009 | 14.7 | 0.008 | 17.1 |
↵4-a AUCtf–∞, AUC from the last measurable sample to infinity.