Table 7

Species comparison of mean noncompartmental pharmacokinetic disposition parameters after iv administration of [¹⁴C]meloxicam

Parameter	Unit	Male Mice (10 mg/kg)	Male Rats (1 mg/kg)	Mini-pigs (10 mg/kg)	Dogs (0.2 mg/kg)	Humans (30 mg)^7-a
t _1/2	hr	6.41	13.4 (21.5%)^7-b	121 (12%)	24.0 (26.2%)	13.7 (14.8%)
MRT	hr	3.02	18.0 (24.0%)	67.4 (34.1%)	34.8 (23.6%)	18.2 (13.0%)
CL	liters/hr/kg	0.155	0.015 (30.7%)	0.043 (22.0%)	0.010 (13.1%)	0.010 (21.8%)
V _ss	liters/kg	0.467	0.257 (6.38%)	2.97 (47.3%)	0.32^7-c (20.9%)	0.18 (20.6%)

↵7-a A total dose of 30 mg in humans is equivalent to 0.43 mg/kg with a total body weight of 70 kg.
↵7-b Values in parentheses, coefficients of variation.
↵7-c V_z.