Pharmacokinetic parameters for theophylline in SDRs and HLRs
| HLRs | SDRs | |
|---|---|---|
| AUC (mg · hr/ml) | 45.0 ± 1.22-a | 70.3 ± 5.6 |
| t 1/2(hr) | 4.25 ± 0.14 | 4.32 ± 0.16 |
| V d(ml/g) | 1.36 ± 0.052-a | 0.89 ± 0.04 |
| K el (hr−1) | 0.16 ± 0.01 | 0.16 ± 0.03 |
| CL (ml/hr/g) | 0.22 ± 0.012-a | 0.14 ± 0.01 |
All values represent mean ± SE (N = 5).Kel, elimination rate constant.
↵2-a P < 0.01, significantly different from SDRs.