Recovery of I and II in rat blood, intestine, and lumen
| Recovery | ||||||||
|---|---|---|---|---|---|---|---|---|
| Blood,I | Intestine | Lumen | Total | |||||
| I | II | I | II | I | II | I+ II | ||
| % of dose | ||||||||
| Without verapamil | 0.3 ± 0.1 | 4.3 ± 2.1 | 0.1 ± 0.1 | 18.2 ± 5.7 | 77.9 ± 10.8 | 23.0 ± 5.8 | 78.0 ± 10.9 | 101.0 ± 6.4 |
| With verapamil | 1.4 ± 0.82-a | 7.6 ± 3.1 | 0.3 ± 0.4 | 22.9 ± 4.9 | 66.0 ± 4.6 | 31.8 ± 5.2 | 66.2 ± 4.8 | 98.1 ± 2.2 |
Results (means ± SD, N = 4) were obtained at the end of a 60-min experiment after administration of II(0.5 mg/2 ml) in rat intestinal loops, with or without verapamil (500 μM).
↵2-a Statistically significant difference (p < 0.05) from control (without verapamil).