Table 2

Summary of the Ki values for the competitive inhibition of CYP3A4-mediated testosterone 6β-hydroxylation by various HIV-PIs and ketoconazole

InhibitorsKi
μM
Ritonavir0.11
Indinavir0.68
Saquinavir4.00
Nelfinavir4.80
Ketoconazole0.10