Table 5

6β-Hydroxycortisol recoveries (μg) in 24-hr urine collections before and during 5–7 days of drug treatment (mean ± SD)

Drug	Number of Patients	Treatment		Percent Change
Drug	Number of Patients	Before	During	Percent Change
NFV	24	148 ± 52	77 ± 32	−40 ± 33
Rifampin/NFV	12	150 ± 30	315 ± 88	+117 ± 85
Ketoconazole NFV	12	134 ± 32	34 ± 18	−74 ± 13

All treatment values were significantly different beforevs. during drug treatment, paired t-testp < 0.0002.