Excretion of radioactivity with urine and bile after single-dose administration of [14C]cerivastatin to rats, dogs, and mice
| Rat | Dog | Mouse | |||||
|---|---|---|---|---|---|---|---|
| Male | Female | Female | Male | ||||
| i.d. (bdc) | Oral | i.d. (bdc) | Oral | i.d. (bdc) | Oral (bdc) | Oral | |
| Dose (mg/kg) | 2 | 20 | 2 | 2 | 2 | 2 | 2 |
| No. of animals | 3 | 5 | 3 | 1 | 1 | 4 | 3 |
| Sampling period (hr) | 0–24 | 0–7 | 0–24 | 0–24 | 0–48 | 0–7 | 0–24 |
| Excretion (%)1-a | |||||||
| Via urine | 0.1 | 1.5 | 4.3 | 3.7 | 0.8 | 0.9 | 3.6 |
| Via bile | 91.3 | — | 77.6 | — | 78.3 | 91.7 | — |
i.d., intraduodenal; bdc, bile duct–cannulated.
↵1-a Amounts excreted are given in percent of dose administered.