Table 1

Summary of disposition after administration of 14C-rifapentine in NMRI mice, bile-cannulated or uncannulated Wistar rats, and Cynomolgus monkeys

MatrixExcreted or Recovered Radioactivity as Percentage of Dose (mean ± SD)1-a
Mouse1-bRat1-cMonkey1-b
10 mg/kg iv (N = 4)10 mg/kg po (N = 6)10 mg/kg iv (cannulated, N = 4)10 mg/kg po (cannulated, N = 4)10 mg/kg po (uncannulated,N = 3)10 mg/kg iv (N = 4)10 mg/kg po (N = 4)40 mg/kg po (N = 6)
Urine
 0–24 hr2.4  ± 0.41.9  ± 0.53.2  ± 1.01.7  ± 0.42.1  ± 0.21.5  ± 0.31.8  ± 0.22.0  ± 0.2
 24–72 hr2.0  ± 0.32.0  ± 0.61.3  ± 0.72.5  ± 1.11.8  ± 0.20.9  ± 0.31.2  ± 0.52.1  ± 0.3
 72-end hr0.5  ± 0.10.6  ± 0.10.3  ± 0.40.0  ± 0.00.5  ± 0.10.4  ± 0.10.3  ± 0.10.4  ± 0.1
Feces
 0–24 hr26.6  ± 7.625.1  ± 7.85.0  ± 1.05.1  ± 1.817.0  ± 5.45.3  ± 4.88.2  ± 6.39.8  ± 6.4
 24–72 hr35.7  ± 4.533.0  ± 9.514.7  ± 5.19.0  ± 5.060.2  ± 1.446.7  ± 11.846.0  ± 5.935.5  ± 6.1
 72-end hr10.7  ± 1.917.4  ± 3.83.5  ± 4.71.3  ± 2.623.0  ± 1.236.1  ± 7.737.9  ± 5.839.8  ± 4.4
Bile
 0–24 hrNA1-e NA12.0  ± 2.59.2  ± 2.0NANANANA
 24–72 hrNANA16.8  ± 2.111.1  ± 4.3NANANANA
 72-end hrNANA1.4  ± 1.61.2  ± 2.0NANANANA
Carcass3.4  ± 1.84.7  ± 3.735.8  ± 4.141.7  ± 14.83.1  ± 0.8NANANA
Mass balance1-d 86.2  ± 3.988.5  ± 2.094.6  ± 3.384.2  ± 1.9108.4  ± 5.791.8  ± 11.295.8  ± 1.389.9  ± 1.3

  • ↵1-a The sum of the percent of dose recovered from cage wash plus cage air was less than 5%.

  • ↵1-b The collection interval for urine and feces samples was 0–120 hr.

  • ↵1-c The collection intervals for urine and feces samples were 0–96 hr in cannulated rats and 0–144 hr in uncannulated rats.

  • ↵1-d Mass balance includes cage wash and cage air counts.

  • ↵1-e NA, not applicable; SD, standard deviation.