Table 4

Metabolite profile in dog plasma extract after oral administration of 2 mg/kg cerivastatin4-a

Metabolite (%)4-bSampling Time (hr)
0.512
Cerivastatin88.285.181.5
M-1 2.34.35.8
M-8 9.59.811.2

  • ↵4-a Established by HPLC; experimental conditions were as described in “Materials and Methods.”

  • ↵4-b Values are given in % of extract.