Table 1

Pharmacokinetic parameters of cIgG, nIgG, cFab, and nFab in IPRL

Parameter	cIgG	nIgG	cFab	nFab	pcIgG-nIgG	p cFab-nFab	p cIgG-cFab
Perfusate
t _1/2λ1(min)	5.216 ± 1.629	—	14.72 ± 3.38	—	—	—	0.0445
t _1/2λz (min)	355.07 ± 17.25	467.44 ± 11.63	552.42 ± 23.70	880.15 ± 39.56	<0.01	<0.01	<0.001
V _Z (ml)	198.66 ± 18.92	130.7 ± 10.5	204 ± 12.37	131.9 ± 0.6	<0.05	<0.05	>0.05
CI _h(ml/min)	0.425 ± 0.03	0.2 ± 0.00	0.275 ± 0.0068	0.1 ± 0.001	<0.01	<0.0001	<0.01
AUC_0-∞ (min·μg/ml)	96.91 ± 11.70	196.51 ± 33.48	84.47 ± 7.80	219.41 ± 39.12	<0.05	<0.01	>0.05
AUC_A(%)	1.62 ± 1.35	—	0.58 ± 0.3	—	—	—	<0.05
E	0.0085 ± 0.0007	0.004 ± 0.0001	0.0055 ± 0.00013	0.002 ± 0.0001	<0.01	<0.0001	<0.01
Bile
% of dose	0.13 ± 0.001	0.018 ± 0.002	0.223 ± 0.04	0.17 ± 0.009	<0.0001	<0.05	<0.01

Data are mean ± SE (N = 4).t_1/2, half-life; V_Z, volume of distribution; CI_h, apparent hepatic uptake clearance; AUC_A (%), percent of the initial phase AUC to the total AUC; E, hepatic extraction ratio. The statistical differences between cIgG and nIgG, cFab and nFab, and cIgG and cFab are shown as p values.