Table 2

Pharmacokinetic parameters of the acid of latanoprost derived from rabbit plasma after topical administration on the eyes using PCnonlin model 82-a

SexMale (N = 3)Female (N = 2)Mean (N = 5)
Weight (W) kg2.87  ± 0.213.11  ± 0.092.96  ± 0.21
Dose (D) μg/animal9.3  ± 0.69.5  ± 0.59.4  ± 0.5
Maximal concentration (C max) ng eq/ml12  ± 313  ± 212.6  ± 2.3
Half-life (t 1/2 alpha) min2.6  ± 2.51.7  ± 0.92.3  ± 1.9
Half life (t 1/2 beta) hr1.41  ± 0.341.43  ± 0.231.42  ± 0.27
Area under the curve (AUClast)2-b ng eq · h/ml2.84  ± 0.443.26  ± 0.493.01  ± 0.46
Plasma clearance (Clp) ml/min · kg8.8  ± 3.26.9  ± 1.98.1  ± 2.7
Volume of distribution (V) liter/kg0.42  ± 0.380.33  ± 0.120.39  ± 0.28

  • ↵2-a Model 8: C(t) = A · exp(−alpha · t) + B · exp(−beta ·t); Cmax = D/V; t1/2 = K10 half-life; CLp = V · K10.

  • ↵2-b AUClast is calculated with model 200.