Table 4

The AUC_inf, C_max, T_max, and elimination half-life (t_1/2) of the acid of latanoprost in the aqueous humor and ocular tissues after the topical application of³H-labeled latanoprost (1.51 MBq; 1.06 μg) to the rabbit eye

Tissues or Body Fluid	AUC_inf(pred.)	t_1/2^4-a	C_max	T_max
	ng eq/mg	hr	ng eq/mg	hr
Aqueous humor	0.37	2.3	0.067	1.00
Cornea	4.31	1.6	1.433	0.25
Iris	0.83	1.8	0.306	0.50
Ciliary body	1.16	2.1	0.339	0.50

↵4-a Time interval (t_1/2) = 1–6 hr; first sampling time = 0.25 hr.