Total spectral cytochrome P450 concentration and percent change in catalytic activities of CYP1A, -2B, -3A, and -4A from liver microsomes obtained from control mice and mice treated orally for 14 days at 1 or 200 mg/kg AT
| Microsome Dose | Total Spectral P4506-a (n = 3) | CYP1A6-b (N = 2) | CYP2B6-c (N= 2) | CYP3A6-d (N = 3) | CYP4A6-e(N = 2) |
|---|---|---|---|---|---|
| mg/kg | |||||
| Control | 0.87 (100)6-f | 1006-b | 100 | 100 | 100 |
| 1.0 | 0.91 (105) | 97 | 135 | 123 | 83 |
| 200.0 | 1.13 (130) | 90 | 79 | 126 | 47 |
↵6-a Nanomoles of P450/mg microsomal protein.
↵6-b Picomoles of resorufin formed/min/mg protein from ethoxyresorufin.
↵6-c Picomoles of resorufin formed/min/mg protein from pentoxyresorufin.
↵6-d Percent formation of 6β-hydroxytestosterone.
↵6-e Percent disappearance of [14C]lauric acid.
↵6-f Percent change from control.