Tissue distribution 3 hr after NDPS administration
| Tissue | Distribution | |
|---|---|---|
| nmol/g of tissue | % of administered dose | |
| Kidneys | 1124.3 ± 148.2 | 1.53 ± 0.24 |
| Liver | 565.0 ± 106.61-a | 2.97 ± 0.58 |
| Testes | 191.3 ± 19.7a,b | 0.45 ± 0.08a,b |
| Adrenal glands | 167.5 ± 31.8a,b | 0.009 ± 0.001a,b |
| Lungs | 124.5 ± 29.5a,b | 0.12 ± 0.02a,b |
| Heart | 113.5 ± 13.5a,b | 0.09 ± 0.02a,b |
| Brain | 109.4 ± 14.9a,b | 0.16 ± 0.03a,b |
| Total | 1519.5 ± 136.9 | 5.33 ± 0.87 |
Male Fischer 344 rats were administered [14C]NDPS (approximately 10 μCi, 0.6 mmol/kg, ip in corn oil) and were sacrificed 3 hr later. The tissues were removed and homogenized. Radioactivity in aliquots of the homogenized tissues was determined by liquid scintillation counting. Values represent means ± SE (N = 3 or 4 rats).
↵1-a Values that are significantly different (p < 0.05) from the corresponding results in the kidneys.
1-b Values that are significantly different (p < 0.05) from the corresponding results in the liver.