Apparent kinetic parameters for BN N-dealkylation by recombinant CYP3A4 and human liver microsomes
| Microsomes1-a | KM | Vmax | Vmax/KM |
|---|---|---|---|
| μM | nmol/min/mg of protein | μl/min/mg of protein | |
| CYP3A4 | 23.7 | 0.592 | 25.0 |
| HL31 | 51.1 | 1.140 | 22.4 |
| HL32 | 43.3 | 0.723 | 16.7 |
| HL35 | 38.3 | 0.644 | 16.8 |
| HL37 | 25.8 | 0.363 | 14.1 |
| HL39 | 38.7 | 0.722 | 18.9 |
| Mean1-b | 39.3 | 0.712 | 17.8 |
| SD1-b | 9.2 | 0.279 | 3.1 |