Metabolite | Metabolites | |||
---|---|---|---|---|
Rat | Rabbit | Dog | Human | |
% of radioactivity | ||||
M1 | ND5-a | ND | ND | 2.6 |
M2 | ND | ND | ND | 3.7 |
M3 | ND | 5.6 | ND | 14.9 |
M4 | ND | 5.4 | ND | ND |
M5a | 22.5 | ND | 5-b | 5-b |
M5b | ND | 17.3 | 5-b | 5-b |
M55-b | (M5a) | (M5b) | ND | 13.3 |
M6a | 8.4 | ND | 5-b | 5-b |
M6b | ND | 2.8 | 5-b | 5-b |
M65-b | (M6a) | (M6b) | 22.4 | 6.7 |
M7 | ND | 3.7 | ND | ND |
M8 | ND | 1.9 | ND | 5-c |
M9 | ND | 11.3 | ND | 13.25-c |
M11 | ND | 8.4 | ND | ND |
M12 | ND | 26.8 | 27.8 | 42.5 |
M13 | 3.3 | ND | ND | ND |
M14 | ND | 16.8 | 21.0 | ND |
M15 | 41.1 | ND | ND | ND |
Desogestrel | 24.8 | ND | 28.8 | ND |
M3, 3-keto-Δ4,6β-hydroxy,13-hydroxyethyl metabolite of desogestrel; M5a,3β-hydroxy,4,5α-dihydro,6α-hydroxy metabolite of desogestrel;M5b, 3-keto-Δ4,6β-hydroxy metabolite of desogestrel; M6a, 3-keto-Δ4,15α-hydroxy metabolite of desogestrel; M6b,3-keto-Δ4,13-hydroxyethyl metabolite of desogestrel;M10, 3α-hydroxy,4,5α-dihydro,15α-hydroxy metabolite of desogestrel; M12, 3-keto metabolite of desogestrel;M13, 3β-hydroxy,4,5α-dihydro metabolite of desogestrel;M14, 3-keto,4,5α-dihydro metabolite of desogestrel.M15, 3α-hydroxy,4,5α-dihydro metabolite of desogestrel;M1, M2, M4, M7, M8, M9, and M11 remained unidentified.
↵5-a ND, not detected.
↵5-b M5a and/or M5b; M6a and/orM6b.
↵5-c M8 and M9 coeluted.