Table 2

Organ uptake parameters for 125I-OX26 in rats treated with either saline, mIgG2a, or OX26 MAb

OrganParameterSalinemIgG2aOX26
Brain V d(μl/g)2-a 149  ± 14134  ± 10139  ± 7
PS (μl/min/g)1.90  ± 0.211.65  ± 0.111.58  ± 0.08
% ID/g0.302  ± 0.0390.320  ± 0.0120.261  ± 0.025
Liver V d (μl/g)719  ± 36750  ± 101057  ± 672-b
PS (μl/min/g)8.15  ± 0.438.41  ± 0.2211.5  ± 0.82-b
% ID/g1.29  ± 0.051.64  ± 0.102-b 1.88  ± 0.152-b

  • Data are mean ± SE (N = 3 rats in each group).

  • ↵2-a Vd, organ volume of distribution.

  • ↵2-b p < 0.05, compared with the saline-treated group, by unpaired Student t test.