Formation of xanomeline N-oxide2-a in a bank of human liver samples after incubation with 2.3, 5.9, or 234 μM xanomeline
| Microsomal Sample | Xanomeline | ||
|---|---|---|---|
| 2.3 μM | 5.9 μM | 234 μM | |
| pmol/min/mg protein | |||
| HLA | 82.9 | 177.7 | 2973.1 |
| HLB | 51.4 | 129.8 | 1867.4 |
| HLC | 57.8 | 125.6 | 1870.3 |
| HLD | 41.2 | 69.8 | 840.4 |
| HLE | 43.6 | 94.1 | 1289.4 |
| HLF | 39.4 | 100.0 | 1431.4 |
| HLG | 61.6 | 212.5 | 3002.8 |
| HLH | 41.4 | 124.3 | 1669.6 |
| HLI | 42.7 | 101.2 | 1577.0 |
| HLJ | 60.2 | 162.3 | 2627.5 |
| HLK | 68.7 | 157.6 | 2177.1 |
| HLL | 60.3 | 130.0 | 1853.2 |
| HLM | 54.6 | 108.2 | 1817.3 |
| HLN | 49.4 | 135.7 | 1361.1 |
↵2-a The conversion rates of xanomeline to these metabolites were determined as indicated in Materials and Methods in duplicate incubations.