Significant correlation between the formation of xanomeline N-oxide and CYP or FMO form-selective activities or formation between different substrate concentrations of xanomeline in a bank of characterized human liver microsomes (n = 14)
| Xanomeline Concentration | Form-Selective Catalytic Activity | Univariater |
|---|---|---|
| μM | ||
| 2.3 | NicotineN′-oxide (FMO) | 0.77 |
| 5.9 | NicotineN′-oxide (FMO) | 0.71 |
| 234 | NicotineN′-oxide (FMO) | 0.66 |
| 2.3 | 5.9 μM Xanomeline | 0.75 |
| 2.3 | 234 μM Xanomeline | 0.82 |
| 5.9 | 234 μM Xanomeline | 0.93 |